{"id":179,"date":"2026-07-13T15:31:51","date_gmt":"2026-07-13T15:31:51","guid":{"rendered":"https:\/\/dcenbd.com\/?post_type=product&#038;p=179"},"modified":"2026-07-13T15:31:51","modified_gmt":"2026-07-13T15:31:51","slug":"luciada-200mg-adagrasib","status":"publish","type":"product","link":"https:\/\/dcenbd.com\/index.php\/product\/luciada-200mg-adagrasib\/","title":{"rendered":"LuciAda 200mg (Adagrasib)"},"content":{"rendered":"<h2>Description:<\/h2>\n<p>LuciAda 200mg is a film-coated oral tablet containing Adagrasib 200 mg, manufactured by Lucius Pharmaceutical Co., Ltd., Vientiane, Laos (WHO-GMP certified). It is a first-in-class, oral, selective KRAS G12C inhibitor used to treat KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC) in adults who have received at least one prior systemic therapy. It is also approved in combination with cetuximab for KRAS G12C-mutated metastatic colorectal cancer (CRC).<br \/>\nLuciAda contains the same active ingredient as\u00a0<a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/216340s005lbl.pdf\" target=\"_blank\" rel=\"noopener\">Krazati\u00ae (Bristol-Myers Squibb \/ Mirati Therapeutics)<\/a>, which received US FDA accelerated approval in December 2022 for NSCLC and in June 2024 for colorectal cancer.<\/p>\n<h2>How LuciAda 200mg Works:<\/h2>\n<p>Adagrasib is a selective, irreversible inhibitor of the KRAS G12C mutation \u2014 a specific genetic alteration that drives uncontrolled cell growth in certain cancers. It permanently locks the mutated KRAS protein in its inactive state by covalently binding to the cysteine residue at position 12, blocking downstream signaling pathways (MAPK and PI3K) that cancer cells rely on to survive and multiply. This precise mechanism spares normal cells, offering a personalized treatment with less collateral damage than traditional chemotherapy.\u00a0<a href=\"https:\/\/www.fda.gov\/drugs\/resources-information-approved-drugs\/fda-grants-accelerated-approval-adagrasib-kras-g12c-mutated-nsclc\" target=\"_blank\" rel=\"noopener\">Read the official FDA approval notice for adagrasib<\/a>.<\/p>\n<h2>Uses:<\/h2>\n<p>LuciAda 200mg is prescribed for:<\/p>\n<ul>\n<li>KRAS G12C-mutated locally advanced or metastatic NSCLC in adults who have received at least one prior systemic therapy (confirmed by an FDA-approved test)<\/li>\n<li>KRAS G12C-mutated metastatic colorectal cancer (CRC) \u2014 in combination with cetuximab \u2014 after prior treatment with fluoropyrimidine, oxaliplatin, and irinotecan-based chemotherapy<\/li>\n<li>Other KRAS G12C-mutated solid tumors as identified in clinical settings<\/li>\n<\/ul>\n<p>A confirmed KRAS G12C mutation diagnosis is required before treatment begins.<\/p>\n<h2>Dosage:<\/h2>\n<table class=\"min-w-full border-collapse text-sm leading-[1.7] whitespace-normal\" width=\"1096\">\n<thead class=\"text-left\">\n<tr>\n<th class=\"text-text-100 border-b-0.5 border-[hsl(var(--border-300)\/0.6)] py-2 pr-4 align-top font-bold\" scope=\"col\">Details:<\/th>\n<th class=\"text-text-100 border-b-0.5 border-[hsl(var(--border-300)\/0.6)] py-2 pr-4 align-top font-bold\" scope=\"col\">Information:<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\"><strong>Recommended dose<\/strong><\/td>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\">600 mg (three 200 mg tablets) orally\u00a0<strong>twice daily<\/strong>\u00a0\u2014 1,200 mg\/day total<\/td>\n<\/tr>\n<tr>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\"><strong>Administration<\/strong><\/td>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\">Swallow tablets\u00a0<strong>whole<\/strong>, with or without food<\/td>\n<\/tr>\n<tr>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\"><strong>Important<\/strong><\/td>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\">Do not crush, chew, or split tablets<\/td>\n<\/tr>\n<tr>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\"><strong>Duration<\/strong><\/td>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\">Continue until disease progression or unacceptable toxicity<\/td>\n<\/tr>\n<tr>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\"><strong>Dose adjustments<\/strong><\/td>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\">Stepwise reduction (600 mg \u2192 400 mg \u2192 300 mg twice daily) for adverse reactions<\/td>\n<\/tr>\n<tr>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\"><strong>Missed dose \/ vomiting<\/strong><\/td>\n<td class=\"border-b-0.5 border-[hsl(var(--border-300)\/0.3)] py-2 pr-4 align-top\">Skip it; take the next dose at the scheduled time \u2014 do not double up<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Always follow your oncologist\u2019s prescription. Full prescribing details are in the\u00a0<a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/216340s005lbl.pdf\" target=\"_blank\" rel=\"noopener\">official FDA label for Krazati (adagrasib)<\/a>. Storage: keep in a dry place at 20\u201325\u00b0C, away from light and out of reach of children.<\/p>\n<h2>Side Effects:<\/h2>\n<p><strong>Common (\u226520%):<\/strong>\u00a0diarrhea, nausea, vomiting, fatigue, musculoskeletal pain, edema, decreased appetite, cough, dizziness, constipation, abdominal pain.<\/p>\n<p><strong>Common laboratory changes:<\/strong>\u00a0raised liver enzymes (AST\/ALT), increased creatinine, low sodium, low hemoglobin, low lymphocyte\/platelet\/magnesium\/potassium, increased lipase.<\/p>\n<p><strong>Serious (seek medical help immediately):<\/strong>\u00a0liver toxicity, lung inflammation (interstitial lung disease\/pneumonitis), kidney impairment, QTc interval prolongation (heart rhythm changes), severe gastrointestinal events.<\/p>\n<p>ECG and electrolyte monitoring is recommended before and during treatment due to QT prolongation risk. Liver and kidney function should be checked regularly. Avoid medicines that further prolong the QT interval where possible.<\/p>\n<h2>FAQ:<\/h2>\n<p><strong>What is LuciAda 200mg used for?<\/strong><br \/>\nLuciAda 200mg is used to treat adults with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC) after at least one prior therapy, and KRAS G12C-mutated metastatic colorectal cancer in combination with cetuximab.<\/p>\n<p><strong>Is LuciAda the same as Krazati?<\/strong><br \/>\nYes. Both contain Adagrasib as the active ingredient. LuciAda is the Lucius Pharmaceutical (Laos) version of Krazati\u00ae.<\/p>\n<p><strong>How many tablets of LuciAda 200mg do I take?<\/strong><br \/>\nThe recommended dose is 600 mg twice daily \u2014 that is three 200 mg tablets in the morning and three in the evening (six tablets per day), with or without food.<\/p>\n<p><strong>Do I need a test before starting?<\/strong><br \/>\nYes. A confirmed KRAS G12C mutation must be detected via an FDA-approved companion diagnostic test (such as the QIAGEN therascreen KRAS RGQ PCR kit for tissue or the Agilent Resolution ctDx FIRST Assay for plasma).<\/p>\n<p><strong>Can LuciAda be taken with food?<\/strong><br \/>\nYes. LuciAda can be taken with or without food. Take it at approximately the same times each day for consistency.<\/p>\n<p><strong>What is the most common side effect?<\/strong><br \/>\nDiarrhea, nausea, and vomiting are the most common. Most are mild to moderate and manageable with supportive care \u2014 speak to your doctor if symptoms are severe or persistent.<\/p>\n<p><strong>Why is heart monitoring needed?<\/strong><br \/>\nAdagrasib can prolong the QTc interval (a measure of heart electrical activity), which may cause abnormal heart rhythms. Your doctor will perform ECGs and check electrolytes (potassium, magnesium) before and during treatment.<\/p>\n<p><strong>Can the dose be reduced for side effects?<\/strong><br \/>\nYes. The dose can be reduced in steps from 600 mg \u2192 400 mg \u2192 300 mg twice daily. Do not adjust the dose yourself \u2014 always consult your oncologist.<\/p>\n<p><strong>Is it safe during pregnancy?<\/strong><br \/>\nNo. Adagrasib can cause harm to an unborn baby. Effective contraception should be used during treatment and for a period after the last dose. Do not breastfeed during treatment. Discuss specifics with your doctor.<\/p>\n<p><strong>How should it be stored?<\/strong><br \/>\nIn a dry place at 20\u201325\u00b0C, away from light, and out of reach of children.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">Product Specifications:<\/h3>\n<ul class=\"[li_&amp;]:mb-0 [li_&amp;]:mt-1 [li_&amp;]:gap-1 [&amp;:not(:last-child)_ul]:pb-1 [&amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\">\n<li class=\"font-claude-response-body whitespace-normal break-words pl-2\"><strong>Active Ingredient:<\/strong>\u00a0Adagrasib 200 mg<\/li>\n<li class=\"font-claude-response-body whitespace-normal break-words pl-2\"><strong>Drug Class:<\/strong>\u00a0Selective KRAS G12C Inhibitor (RAS GTPase family inhibitor)<\/li>\n<li class=\"font-claude-response-body whitespace-normal break-words pl-2\"><strong>Manufacturer:<\/strong>\u00a0Lucius Pharmaceutical Co., Ltd., Vientiane, Laos \u2014 WHO-GMP certified<\/li>\n<li class=\"font-claude-response-body whitespace-normal break-words pl-2\"><strong>Reference Brand:<\/strong>\u00a0Krazati\u00ae (Bristol-Myers Squibb \/ Mirati Therapeutics)<\/li>\n<li class=\"font-claude-response-body whitespace-normal break-words pl-2\"><strong>Form:<\/strong>\u00a0Film-coated oral tablet<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Get\u00a0<strong>LuciAda 200mg<\/strong> delivered directly to your doorstep \u2014 anywhere in the world. Dcenbd is a trusted source of certified cancer and specialty medicines, sourced directly from licensed manufacturers.<\/p>\n","protected":false},"featured_media":180,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[35],"product_cat":[19],"product_tag":[],"class_list":["post-179","product","type-product","status-publish","has-post-thumbnail","product_brand-dcenbd-export-all-kind-of-medicine-from-lucius-pharmaceuticals","product_cat-lung-cancer","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/product\/179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/comments?post=179"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/media\/180"}],"wp:attachment":[{"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/media?parent=179"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/product_brand?post=179"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=179"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}