{"id":103,"date":"2026-07-06T16:50:11","date_gmt":"2026-07-06T16:50:11","guid":{"rendered":"https:\/\/dcenbd.com\/?post_type=product&#038;p=103"},"modified":"2026-07-17T19:42:47","modified_gmt":"2026-07-17T19:42:47","slug":"riibokis-200mg","status":"publish","type":"product","link":"https:\/\/dcenbd.com\/index.php\/product\/riibokis-200mg\/","title":{"rendered":"RIBOKIS 200mg (Ribociclib)"},"content":{"rendered":"<p class=\"PDq2pG_selectionAnchorContainer\" data-start=\"386\" data-end=\"751\">Ribociclib belongs to a class of medicines known as <strong data-start=\"438\" data-end=\"486\">cyclin-dependent kinase (CDK) 4\/6 inhibitors<\/strong>. It works by blocking the activity of CDK4 and CDK6 proteins, which are involved in promoting the growth and division of cancer cells. By inhibiting these proteins, Ribokis helps slow or stop the proliferation of cancer cells, thereby delaying disease progression.<\/p>\n<h3 data-section-id=\"ycgkk5\" data-start=\"753\" data-end=\"769\">Key Benefits:<\/h3>\n<ul data-start=\"771\" data-end=\"1036\">\n<li data-section-id=\"n7n628\" data-start=\"771\" data-end=\"854\">Indicated for <strong data-start=\"787\" data-end=\"854\">HR-positive, HER2-negative advanced or metastatic breast cancer<\/strong><\/li>\n<li data-section-id=\"1cx7rby\" data-start=\"855\" data-end=\"889\">A selective <strong data-start=\"869\" data-end=\"889\">CDK4\/6 inhibitor<\/strong><\/li>\n<li data-section-id=\"sw1j17\" data-start=\"890\" data-end=\"940\">Helps slow the growth and spread of cancer cells<\/li>\n<li data-section-id=\"1bjz5zi\" data-start=\"941\" data-end=\"1005\">Commonly used in combination with endocrine (hormonal) therapy<\/li>\n<li data-section-id=\"12sc4ve\" data-start=\"1006\" data-end=\"1036\">Prescription-only medication<\/li>\n<\/ul>\n<blockquote data-start=\"1038\" data-end=\"1269\" data-is-last-node=\"\" data-is-only-node=\"\">\n<p data-start=\"1040\" data-end=\"1269\" data-is-last-node=\"\"><strong data-start=\"1040\" data-end=\"1054\">Important:<\/strong> Ribokis should be taken only under the supervision of a qualified healthcare professional. The dosage and treatment schedule should be determined by the treating physician based on the patient&#8217;s clinical condition.<\/p>\n<\/blockquote>\n<p>&nbsp;<\/p>\n<p>Ribokis 200 Mg is ananti-cancer medicine classified as a picky cyclin-dependent kinase( CDK) 4 and 6 asset, retailed in Bangladesh under the brand name Ribokis( general of Kisqali brand). In addition, intended to reduce the growth of hormone receptor \u2013 positive( HR) and HER2 \u2011 negative advanced or metastatic bone cancer by inhibiting critical proteins that propel the proliferation of cancer cells.<\/p>\n<p>&nbsp;<\/p>\n<h2>Action:<\/h2>\n<p>Ribokis 200 Mg functions by inhibiting CDK4 and CDK6 enzymes. CDK4 and CDK6 enzymes, after activation with cyclin. In addition, d, phosphorylate the retinoblastoma protein( pRb), causing G1 to S phase progression of the cell cycle. Inhibiting CDK4\/ 6, ribociclib results in cancer cell inhibition in the G1 phase, inhibiting proliferation.<\/p>\n<p>Preclinical studies show ribociclib reduces pRb phosphorylation in bone cancer cell lines, performing in tumour retrogression utmost successfully used in combination with hormone curatives similar as letrozole or fulvestrant.<\/p>\n<p>&nbsp;<\/p>\n<h2>suggestion:<\/h2>\n<p>Ribociclib is approved for adult cases with HR, HER2 \u2011 negative advanced or metastatic bone cancer, in combination with<\/p>\n<p>Aromatase impediments( eg, letrozole) as original endocrine remedy<\/p>\n<p>Fulvestrant, either as first- line treatment or in case of progression<\/p>\n<p>Pre- or perimenopausal women, with luteinizing- hormone \u2013 releasing hormone analogues<\/p>\n<p>Recent blessings( Sept 2024 USA, Nov 2024 EU) have also made it available for high- threat early- stage bone cancer( Stage II\/ III) in the adjuvant setting.<\/p>\n<h3 style=\"margin: 0in; margin-bottom: .0001pt; background: white;\"><span style=\"font-size: 22.5pt; font-family: 'Arial',sans-serif; color: #192a3d;\">Dosing:<\/span><\/h3>\n<p style=\"margin: 0in; margin-bottom: .0001pt; background: white; outline: none; box-sizing: border-box; border-color: currentcolor; border-image: initial; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; font-language-override: inherit; max-width: 1290px; margin-block: 0px 24px; width: min(100%, 1229.4px); orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;\"><span style=\"font-family: 'Segoe UI',sans-serif; color: #3a4f66;\">Usual authority 600 mg( three 200 mg tablets) once a day, with or without food, for 21 days, followed by a medicine-free interval of 7 days; the cycles are repeated every 28 days<\/span><\/p>\n<p style=\"margin: 0in; margin-bottom: .0001pt; background: white; outline: none; box-sizing: border-box; border-color: currentcolor; border-image: initial; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; font-language-override: inherit; max-width: 1290px; margin-block: 0px 24px; width: min(100%, 1229.4px); orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;\"><span style=\"font-family: 'Segoe UI',sans-serif; color: #3a4f66;\">Cure adaptation Cure reduction to 400 mg or 200 mg may be necessary for cure- limiting venom( e.g., Grade 3 neutropenia); in case of patient toxin on 200 mg, termination is advised.<\/span><\/p>\n<p style=\"margin: 0in; margin-bottom: .0001pt; background: white; outline: none; box-sizing: border-box; border-color: currentcolor; border-image: initial; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; font-language-override: inherit; max-width: 1290px; margin-block: 0px 24px; width: min(100%, 1229.4px); orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;\"><span style=\"font-family: 'Segoe UI',sans-serif; color: #3a4f66;\">Missed cure If puking occurs or if a cure is missed, do n\u2019t take an redundant cure on that day \u2014 capsule coming listed cure.<\/span><\/p>\n<p style=\"margin: 0in; margin-bottom: .0001pt; background: white; outline: none; box-sizing: border-box; border-color: currentcolor; border-image: initial; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; font-language-override: inherit; max-width: 1290px; margin-block: 0px 24px; width: min(100%, 1229.4px); orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;\"><span style=\"font-family: 'Segoe UI',sans-serif; color: #3a4f66;\">Special populations gestation and lactation are contraindicated( fetal detriment verified in beast studies).<\/span><\/p>\n<p style=\"margin: 0in; margin-bottom: .0001pt; background: white; outline: none; box-sizing: border-box; border-color: currentcolor; border-image: initial; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; font-language-override: inherit; max-width: 1290px; margin-block: 0px 24px; width: min(100%, 1229.4px); orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;\"><span style=\"font-family: 'Segoe UI',sans-serif; color: #3a4f66;\">Use effective contraception during treatment and for at least 3 weeks after.<\/span><\/p>\n<p style=\"margin: 0in; margin-bottom: .0001pt; background: white; outline: none; box-sizing: border-box; border-color: currentcolor; border-image: initial; font-variant-ligatures: normal; font-variant-caps: normal; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: inherit; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; font-language-override: inherit; max-width: 1290px; margin-block: 0px 24px; width: min(100%, 1229.4px); orphans: 2; text-align: start; widows: 2; -webkit-text-stroke-width: 0px; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; word-spacing: 0px;\"><span style=\"font-family: 'Segoe UI',sans-serif; color: #3a4f66;\">Acclimate boluses for severe\/ moderate liver or order impairment.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h4>Monitoring:<\/h4>\n<p>birth &amp; ongoing ECG and electrolytes( K \u207a, Mg \u00b2 \u207a, Ca \u00b2 \u207a, phosphorus) on launch and on Day 14 of Cycle 1, also Cycle<\/p>\n<p>CBC Q 2 weeks for cycles 1 and 2, also yearly or as clinically indicated<\/p>\n<p>Liver function tests( AST\/ ALT) Q 2 weeks during Cycle 2, also q 4 weeks.<\/p>\n<p>Clinical monitoring: In addition, examiner for substantiation of infection, cardiac complications, respiratory torture, severe skin response or liver abnormalities.<\/p>\n<p>&nbsp;<\/p>\n<h3>Pharmacies:<\/h3>\n<h3 class=\"PDq2pG_selectionAnchorContainer\" data-section-id=\"rolljd\" data-start=\"103\" data-end=\"123\">Pharmacokinetics<\/h3>\n<ul data-start=\"125\" data-end=\"453\">\n<li data-section-id=\"15tctzw\" data-start=\"125\" data-end=\"196\"><strong data-start=\"127\" data-end=\"165\">Time to Peak Concentration (Tmax):<\/strong> 1\u20134 hours after administration<\/li>\n<li data-section-id=\"1l12war\" data-start=\"197\" data-end=\"249\"><strong data-start=\"199\" data-end=\"228\">Steady-State Achievement:<\/strong> Approximately 8 days<\/li>\n<li data-section-id=\"1mvaioi\" data-start=\"250\" data-end=\"298\"><strong data-start=\"252\" data-end=\"272\">Protein Binding:<\/strong> ~70% plasma protein-bound<\/li>\n<li data-section-id=\"1d2lv61\" data-start=\"299\" data-end=\"352\"><strong data-start=\"301\" data-end=\"316\">Metabolism:<\/strong> Primarily metabolized by <strong data-start=\"342\" data-end=\"352\">CYP3A4<\/strong><\/li>\n<li data-section-id=\"kvfpru\" data-start=\"353\" data-end=\"404\"><strong data-start=\"355\" data-end=\"381\">Elimination Half-Life:<\/strong> Approximately 32 hours<\/li>\n<li data-section-id=\"15vn2kx\" data-start=\"405\" data-end=\"453\"><strong data-start=\"407\" data-end=\"421\">Excretion:<\/strong> 69% via feces and 23% via urine<\/li>\n<\/ul>\n<h3 class=\"\" data-section-id=\"nkemc6\" data-start=\"455\" data-end=\"488\">Common &amp; Serious Side Effects:<\/h3>\n<p data-start=\"490\" data-end=\"558\">The following adverse reactions have been reported during treatment.<\/p>\n<h4 data-start=\"560\" data-end=\"576\">Hematologic:<\/h4>\n<ul data-start=\"577\" data-end=\"651\">\n<li data-section-id=\"1pou7s8\" data-start=\"577\" data-end=\"596\">Neutropenia (77%)<\/li>\n<li data-section-id=\"1n22f43\" data-start=\"597\" data-end=\"609\">Leukopenia<\/li>\n<li data-section-id=\"1w69v6v\" data-start=\"610\" data-end=\"618\">Anemia<\/li>\n<li data-section-id=\"66zdcr\" data-start=\"619\" data-end=\"637\">Thrombocytopenia<\/li>\n<li data-section-id=\"1keimb8\" data-start=\"638\" data-end=\"651\">Lymphopenia<\/li>\n<\/ul>\n<h4 data-start=\"653\" data-end=\"665\">Hepatic:<\/h4>\n<ul data-start=\"666\" data-end=\"727\">\n<li data-section-id=\"1x7f9kp\" data-start=\"666\" data-end=\"696\">Increased AST and ALT levels<\/li>\n<li data-section-id=\"17iejk4\" data-start=\"697\" data-end=\"727\">Hepatobiliary toxicity (24%)<\/li>\n<\/ul>\n<h4 data-start=\"729\" data-end=\"750\">Gastrointestinal:<\/h4>\n<ul data-start=\"751\" data-end=\"820\">\n<li data-section-id=\"ulklaf\" data-start=\"751\" data-end=\"765\">Nausea (53%)<\/li>\n<li data-section-id=\"1woo0av\" data-start=\"766\" data-end=\"782\">Diarrhea (38%)<\/li>\n<li data-section-id=\"xwb6hx\" data-start=\"783\" data-end=\"799\">Vomiting (33%)<\/li>\n<li data-section-id=\"1la40yv\" data-start=\"800\" data-end=\"820\">Constipation (28%)<\/li>\n<\/ul>\n<h4 data-start=\"822\" data-end=\"855\">Other Common Adverse Effects:<\/h4>\n<ul data-start=\"856\" data-end=\"1006\">\n<li data-section-id=\"syrtno\" data-start=\"856\" data-end=\"871\">Fatigue (41%)<\/li>\n<li data-section-id=\"10fqg2f\" data-start=\"872\" data-end=\"888\">Alopecia (34%)<\/li>\n<li data-section-id=\"xffcxw\" data-start=\"889\" data-end=\"901\">Rash (22%)<\/li>\n<li data-section-id=\"1s6kozz\" data-start=\"902\" data-end=\"912\">Headache<\/li>\n<li data-section-id=\"16x9nwe\" data-start=\"913\" data-end=\"920\">Cough<\/li>\n<li data-section-id=\"dytpg5\" data-start=\"921\" data-end=\"932\">Back pain<\/li>\n<li data-section-id=\"1wkwpwg\" data-start=\"933\" data-end=\"945\">Infections<\/li>\n<li data-section-id=\"1xerr7i\" data-start=\"946\" data-end=\"973\">Elevated serum creatinine<\/li>\n<li data-section-id=\"1l428z\" data-start=\"974\" data-end=\"1006\">Increased blood glucose levels<\/li>\n<\/ul>\n<h3><strong>Ribociclib (Ribokis) <\/strong><\/h3>\n<h3><strong>Manufactured by Everest Pharmaceutical Ltd.<\/strong><\/h3>\n","protected":false},"excerpt":{"rendered":"<h1><strong>Ribokis (Ribociclib), generic KISQALI is a prescription medicine used to treat patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. Ribociclib is in a class of medicine called kinase inhibitors. Ribociclib works by blocking the action of an abnormal protein that signals cancer cells to multiply. Ribociclib helps slow or stop the spread of Cancer cells.<\/strong><\/h1>\n","protected":false},"featured_media":105,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[36],"product_cat":[21],"product_tag":[],"class_list":["post-103","product","type-product","status-publish","has-post-thumbnail","product_brand-everest-pharmaceuticals-ltd","product_cat-breast-cancer","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/product\/103","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/comments?post=103"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/media\/105"}],"wp:attachment":[{"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/media?parent=103"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/product_brand?post=103"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/product_cat?post=103"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/dcenbd.com\/index.php\/wp-json\/wp\/v2\/product_tag?post=103"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}