Introduction
Palboxen 125 is used to treat patients with certain types of breast cancer (estrogen receptor-positive, human epidermal growth factor receptor 2-negative) which have spread to other organs. It is given together with hormonal anticancer therapies. Palboxen 125 should be taken with food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Some common side effects of this medicine include fatigue, hair loss, rash, vomiting, and diarrhea. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. It is better to inform your doctor if you notice symptoms of infection like fever, chills, and weakness, bleeding or bruising and nose bleed. It might also cause dizziness if it happens avoid driving or attention-seeking activities. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Palboxen 125 Breast cancer.
Side effects of Palboxen 125:
Common :
- Fatigue
- Hair loss
- Rash
- Vomiting
- Diarrhea
- Nausea
- Decreased blood cells (red cells, white cells, and platelets)
- Infection
- Decreased appetite
- Fever
How to use Palboxen 125:
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Palboxen 125 is to be taken with food.
How Palboxen 125 works
Palboxen 125 is an anti-cancer medication. Cyclin dependent kinase 4 and 6 (chemical messengers) are downstream of signaling pathways which lead to the proliferation of cells. This medicine works by inhibiting cyclin dependent kinase 4 and 6, thus arrests the cancer cell cycle (cell growing process). It also targets the estrogen (hormone) receptor-positive breast cancer cells by disrupting the cell cycle.
Adult Dose:
Oral Hormone receptor positive, HER2-negative locally advanced carcinoma of breast, Hormone receptor positive, HER2-negative metastatic carcinoma of breast Adult: In combination with aromatase inhibitor, or in combination with fulvestrant in women who have received prior endocrine therapy: 125 mg once daily for 21 days, followed by 7 days off, repeat every 28 days until disease progression or unacceptable toxicity. Dosage Modifications Dose reduction, dosing interruption, or discontinuation may be required according to individual safety or tolerability (refer to detailed product guideline). Recommended dose reduction: 1st reduction: 100 mg once daily; 2nd reduction: 75 mg once daily; discontinue if dose reduction below 75 mg once daily is required. Hepatic impairment Mild or moderate (Child-Pugh A or B): No dose adjustment required Severe (Child-Pugh C): Reduce dose to 75 mg/day for Days 1-21 of each 28-day cycle
Side Effects:
Common side effects of Palboxen include: WBC decreased, Neutrophils decreased, Neutropenia, Platelets decreased, infections, AST increased, ALT increased, Leukopenia, Fatigue, Nausea, Hair loss, Inflammation of the mouth and lips, Diarrhea, Anemia, Rash, Weakness/lethargy, Vomiting, Thrombocytopenia, Dry skin, Fever.
Overdose Effects:
There is no known antidote for Palboxen. The treatment of overdose of Palboxen should consist of general supportive measures.
Therapeutic Class:
Protein kinase inhibitor
Storage Conditions:
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Reviews
There are no reviews yet.